Cooperative triple catalysis enables regioirregular formal Mizoroki–Heck reactions

Abstract The Mizoroki–Heck reaction between alkenes and aryl halides represents one of the most important methods for C?C bond formation in synthetic chemistry. Governed by their electronic steric nature, are generally arylated with high regioselectivity, which conversely hampers diversity, particular, if regioirregular isomer is targeted. Usually, electron-poor selectively afford corresponding ?-coupled products, achieving opposite regioselectivity to obtain ?-arylated congeners highly challenging. It would be desirable access irregular ?-regioisomer simple variation conditions, keeping standard substrates, thereby significantly enlarging product space. Herein, we describe an intermolecular ?-arylation through cooperative nickel, photoredox sulfinate catalysis. This triple catalysis system operates under mild conditions features excellent functional group tolerance. orchestration radical, transition metal ionic bond-forming -cleaving reactions a single process challenging, but certainly opens valuable doors terms reactivity. Moreover, ?-arylation, ?-alkenylation ?-alkynylation styrenes could also achieved one-pot process.